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These experiments essentially exclude a metabolic role for extrahepatic FX synthesis in the activation of PAR2 outside of the vascular system but delineate an important regulatory role of FXa-PAR2 signaling in controlling ATM activation and adipose tissue inflammation

Implementation Intervention or control capsules were administered orally or with enteral nutrition (enteral tube feeding) three times a day at 9:00, 15:00, and 21:00

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The cardiac toxicity of hypertyrosinemia itself is unknown