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[PubMed: 27151488] (49 year old woman developed jaundice 4 weeks after starting Hydroxycut for weight loss [bilirubin 6.9 mg/dL, ALT 115 U/L, Alk P 299 U/L], which improved after stopping but was followed by persistent Alk P elevations [237 to 253 U/L] without jaundice while liver biopsy showed bile duct loss)

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An alternative interpretation is that SYGL-1 and LST-1 are required for optimal activity of PUF hub components, rather than target selectively

This includes assessing the patient's overall health, medical history, and current medications to identify any potential contraindications