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Mehan S, Bhalla S, Siddiqui EM, Sharma N, Shandilya A, Khan A (2022) Potential Roles of Glucagon-Like Peptide-1 and Its Analogues in Dementia Targeting Impaired Insulin Secretion and Neurodegeneration

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A series of mixed, generalized linear models were conducted to look for differences between the CRWP and placebo groups for the physiological assessments

After the impact, the influx of Ca 2+ ions into the cell cytoplasm leads to the phosphorylation/activation of phospholipases that cleave phospholipids into fatty acids, diaglycerols and lysophospholipids like LPC, which initiates signaling cascades that drive inflammation, BBB destruction, demyelination, and protein aggregation in several neurodegenerative contexts [81]

Consistent with this positive correlation between glutamine breakdown and mTORC1, FOXO-mediated GS expression inhibits mTOR signaling by blocking its lysosomal translocation

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