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If you have no known MTHFR variants and simply want an affordable, well-verified B12 supplement, Nature Mades cyanocobalamin softgel is hard to beat

Be transparent with your healthcare provider about every medication you're on to prevent potential drug interactions and optimize your dosage

However, they may not be suitable for individuals with allergies to certain ingredients, pregnant or breastfeeding women, or those with specific health conditions such as liver or kidney disease

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If you're struggling with obesity or significant weight gain, it's worth discussing these prescription options with your doctor rather than relying solely on supplements like berberine