These findings emphasize that targeted antagonism of NMDA receptor signalling lowers body weight independently of MC4R, indicating that this preclinical drug candidate might not only be effective in treating polygenic obesity but also holds potential as an effective weight loss strategy for patients with loss-of-function mutations in MC4R , the most common form of monogenic obesity 32
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Childhood obesity facts
Some researchers have also voiced concern that a 25 to 30 percent reduction in body weight could compromise some patients health, perhaps by leading to nutritional deficiencies or loss of muscle mass
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