Apart from the local adverse effects of these agents, the important limitation is the localization of their effect to the site of application alone
According to a meta-analysis conducted in 2020 reported circadian variation in 15 of 19 studies on total fat concentration (with peaks in the evening hours), while the remaining studies yielded different results [3]
[4] [6] Importantly, no clear association has been established between the heart rate increase with GLP-1 therapy and adverse cardiovascular outcomes
Detailed blood parameters are described in Table 4
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Zhang, Q., Sun, X., Ruan, H., Yin, K