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95.0% CI: 0.75-0.94), suggesting broader survival benefits that extend beyond cardiovascular end points

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For instance, patients with lower GLP1R sensitivity may benefit from oral semaglutide (at $289/mo month-to-month, or from $249/mo on the 6-month plan) paired with shorter, more frequent fasting windows, while those with high FTO variants often thrive on fewer, longer eating windows with concentrated calorie intake

Start with one compound (typically Semaglutide), titrate to your target dose, and stabilize before adding MOTS-c

These predispositions do not determine outcome but may provide context for provider conversations about optimal dosing approach and expected response timeline