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In these systems, drugs are encapsulated or conjugated to nanoparticles that can penetrate biological barriers, thereby facilitating direct delivery to specific tissues or cells

Pharmacologically mediated marked initial maternal body weight loss and reductions in body weight gain and food consumption coincided with an increase in early pregnancy losses and led to delivery of slightly smaller offspring at 0.075 mg/kg twice weekly (6X human exposure)

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Biol Psychiatry (1996) 40(11):11227

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