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However, conducting clinical trials on anti-obesity medications in pediatric populations presents several unique challenges

Hepatocellular hypertrophy is typically identified by light microscopy and is associated with increased protein synthesis (assessed biochemically) and increased cytoplasmic organelles such as endoplasmic reticulum and peroxisomes (assessed by electron microscopy), or accumulation of intracellular components such as glycogen, lipid, or water

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Trends that fail to reach significance in meta-analyses of 45 trials are, by definition, small effects that may or may not be real