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Moreover, the increased renal RAS activity might have been important in maintaining a normal glomerular filtration in this setting

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GLP-1R agonists also demonstrate neuroprotective effects, including reduction of neuroinflammation, oxidative stress, and neuronal apoptosis, with emerging evidence for benefit in neurodegenerative diseases such as Parkinsons and Alzheimers disease [75, 76]

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Constipation can be managed with osmotic laxatives (macrogol) or stimulant laxatives if needed