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MEK1 and MEK2, the primary subtypes involved in ERK activation, are regulated by the RAF family of proteins, which includes A-Raf, B-Raf and C-Raf (69,70)

References 1 GreggEWBuckleyJAliMKDaviesJFloodDMehtaRet al

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Risk factors for early or premature menopause are smoking, chemotherapy and radiation during cancer treatment, family history, chronic stress (such as PTSD), and certain diseases like autoimmune-related thyroid disease