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Most patients start with the lowest available dose to minimize side effects and allow the body to gradually adapt to the medication

The more important factor is rotating consistently and using correct technique

Newer agents like survodutide , orforglipron , or mazdutide are in various stages of development and clinical use, and retatrutide (a triple agonist targeting GIP, GLP-1, and glucagon receptors) shows even greater weight loss potential than tirzepatide in early trials

JAMA Surgery

Since GLP-1 drugs slow gastric emptying, they shouldnt be used in people with gastroparesis

Humans have shared anecdotal reports about how taking GLP-1RAs for other indications helped them reduce their alcohol consumption as well