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The following information is drawn from the company's published safety disclosures and general prescribing information

In the face of vitamin B 12 deficiency, conversion of methylmalonyl-CoA to succinyl-CoA cannot take place, which results in accumulation of methylmalonyl-CoA and aberrant fatty acid synthesis

While retatrutide shows impressive results in early studies (e.g., significant body weight reductions), individual responses vary