Glucagon-like Peptide-1 (GLP-1, 3031 aa) is a natural gastrointestinal incretin hormone of the glucagon peptide family, secreted from the enteroendocrine L-cells in the distal gut to stimulate insulin secretion in response to postprandial hyperglycemia (Figure 1)
In studies, average weight loss with tirzepatide is slightly over 20% of body weight
The extreme fluctuations between hyperglycemia and relative hypoglycemia can cause significant tiredness, brain fog, and lethargy
For semaglutide-related constipation, longer-term use may be appropriate under clinician guidance
Semaglutide GLP-1 Weight Loss Specialist in Barrington, IL Semaglutide GLP-1 is a highly effective treatment for weight loss, designed to reduce hunger and promote feelings of fullness
View the Phase 2 retatrutide trial on PubMed