Based on this pharmacokinetic profile, administration of cagrilintide to participants with varying degrees of renal or hepatic impairment is expected to yield comparable exposure across dose levels and dosing frequencies, without compromising safety
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Furthermore, measurements have shown that human breast tumors display plastic deformation (i.e., permanent deformation when subjected to external forces) [144], likely due to the increased collagen concentration and crosslinking observed in the breast tumor microenvironment which can enhance plasticity [145]
doi: 10.1038/nchembio.2239 68 DixonSJWinterGEMusaviLSLeeEDSnijderBRebsamenMet al
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