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This is supported by Jun et al.s work demonstrating that ACN from gooseberry inhibited hepatic fibrosis by blocking the TGF-/Smad signaling pathway, and reduced the deposition of -smooth muscle actin (-SMA) protein and the expression of collagen I (Yang et al., 2020)

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Glutathione functions through two primary mechanisms: direct scavenging of reactive oxygen species (ROS) and serving as a cofactor for glutathione peroxidase, a family of enzymes that neutralize hydrogen peroxide and lipid peroxides [2][4]

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These findings suggested that SELS and SEPP1 may play important roles in ER stress regulation