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Most trials focus on intermediate outcomes such as weight, fat mass, exercise markers, or cognition

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The safe alternative options include tirzepatide (a dual agonist), Rybelsus (an oral pill), or classic appetite suppressants

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5h), while the mRNA levels of M2 macrophage markers such as arginase-1 (Arg-1) and interleukin-10 (IL-10) were upregulated, further confirming the phenotype reprograming of the macrophages and the anti-inflammatory potential of ZMTP nanosheets