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On the other hand, certain stressors (e.g., uremic toxins) activate the AHRHsp90MDM2 axis, promoting VDR ubiquitination and degradation (18), which aggravates local inflammation

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It can produce transient insulin resistance through GH-mediated lipolysis and hepatic glucose output

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As a member of the IGFBP family, IGFBP-4 influences the inflammatory regulation of the tumor microenvironment