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Dermal edema and erythrocyte extravasation may be present, as well as spongiosis, a pseudolymphomatous reaction, and focal epidermal necrosis.43,44 Laboratory alterations Eosinophilia, in varying degrees, is one of the characteristics of the syndrome, is present in up to 95.5% of cases at some stage of the disease and may persist after the normalization of liver enzymes.32,45 Several cytokines are involved in the activation and recruitment of eosinophils

Two components contribute to CAI

Within an in vivo IDD rat model, these nanoparticles outperformed single DFOM or CeO2 treatments, preserving intervertebral disc height and reducing ECM degradation (96)

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