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Common side effects include: Nausea Vomiting Diarrhea Constipation Abdominal pain These are typically mild and lessen over time

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But black, tarry, foul-smelling stool may be melena from gastrointestinal bleeding and can be an emergency

What this means for underwriting GLP1s demand a shift in mindset

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That is the most plausible explanation for why the same drug produces diarrhea in roughly three in ten trial participants and constipation in roughly one in four