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Endothelial ion transporters, including the Na-H and Na-K-Cl cotransporter, become dysregulated upon neuronal injury, resulting in an imbalance of ionic gradients and cytotoxic edema that contribute to secondary neuronal damage (Pinheiro et al., 2016)

Zinc acts as a cofactor for the antioxidant enzyme superoxide dismutase (SOD), which protects cells from oxidative stress and damage

beta-amyloid protein induces mitophagy-dependent ferroptosis through the CD36/PINK/PARKIN pathway leading to blood-brain barrier destruction in Alzheimers disease

Selective serotonin reuptake inhibitors (SSRIs), commonly prescribed for depression, can increase the risk of bleeding when combined with ibuprofen

Which can be harmful