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However, a dose-dependent insulinotropic and glucagonostatic response is preserved in response to exogenous GLP-1 treatment and 6-week subcutaneous GLP-1 infusion was shown to improve HbA1c levels by 1.3% [18]

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The researchers defined 16 GLP-1RA treatment scenarios for GLP-1RA users by semi-annually reassigning their treatment status, conditional on their current use status, thereby emulating dynamic treatment strategies over time