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doi: 10.1186/1471-2180-14-189 249 BerntsonGGKhalsaSS

(2015) implicated activation of the necroptosis pathway as contributing to progressive MS, finding that ~50% genes upregulated in chronic active lesions are regulators of this process 50

Notably, while some subunits of spliceosome complexes normally recruited during its activation (e.g., NTR, NTC, IBC) were still incorporated (e.g., SNW1, RBM22, PRPF19, AQR), the others were decreased (e.g., BCAS2, CDC5L, CWC22)

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