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Documented research applications Used in vitro and in animal model studies investigating: Multi-receptor incretin signalling and synergy Adipocyte energy expenditure and lipolysis pathways Hepatic glucose output regulation Comparative pharmacology vs

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PA then diffuses back into the bacilli, where it accumulates and exerts multiple effects against Mtb, including inhibition of fatty acid synthase, disruption of membrane potential, and interference with energy production by interacting with ribosomal protein S1 to inhibit trans-translation (Zimhony et al., 2007

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Synthesis and biological activity of NK-1 selective, N-backbone cyclic analogs of the C-terminal hexapeptide of substance P