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Those who maintain a vegan diet are also at high risk of developing a vitamin B12 deficiency since meats and other animal by-products are some of the best sources of B12

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A systematic review of tirzepatide research found that lean tissue loss accounts for approximately 20% to 34% of total weight lost

The liver stores vitamin B12, sometimes in amounts sufficient for years, which is why deficiency can develop slowly

But in the case of B12 deficiency, homocysteine may rise beyond normal levels, causing irritation to the cardiovascular system and increasing inflammation

Despite the low recommended intake deficiency is still common, especially in those who follow a vegan or vegetarian diet