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SOD-dependent catalysis of NO formation from RSNOs occurs in the presence of GSH, which reduces the active site copper in SOD to the cuprous oxidation state, which in turn rapidly reduces GSNOs to NO (27)

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Epub 2009 Feb 28

Development of a temporary threshold shift model of chronic noise-induced tinnitus with evidence of altered auditory signaling pathway inhibition

11,62,796 Moreover, complex crosstalk between extrahepatic and intracellular pathways, as well as the presence of multiple isoforms of key metabolic enzymes, can limit the effectiveness of such treatments