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Following the absorption of sugar, GLP-1 and GIP secreted by cells of the intestine make it possible to very significantly increase the production of insulin by the pancreas, at levels much higher than those that are produced simply in response to the presence of sugar in the blood (Figure 1)

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Refinement of Glucagon-like Peptide 1 Docking to Its Intact Receptor Using Mid-region Photolabile Probes and Molecular Modeling

The latter is chemically unstable due to the reactive carbon of the isothiocyanate group (N=C=S) that easily reacts with nucleophiles such as thiols

Unlike true anaphylaxis, these reactions are non-IgE-mediated and result from direct histamine release from mast cells and basophils rather than immune system sensitization