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Metabolic Adaptation and Plateau Phases Weight loss plateaus are a normal physiological response, not a medication failure

used tirzepatide at up to 15 mg weekly for 52 weeks, while Blackman et al

Adults try to follow a special diet each year

Peptide drug treatment Mice were treated via subcutaneous (s.c.) injection at the indicated doses with either long-acting acyl-GIP (100 nmol kg 1 s.c.), LIRA (100 nmol kg 1 s.c.) or an acylated peptide GIPR antagonist ([N-Ac,L14,R18,E21]hGIP(531)-K11(E-C16)) (1500 nmol kg 1 s.c.)

Blood pressure measurements, particularly orthostatic vital signs (comparing readings while lying down and after standing for 1-3 minutes), can help identify postural hypotension