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NICE's initial estimates assumed weight would return to baseline over two to three years our data suggests this happens in around 18 months

Third, our approach: we'd rather under-treat and have you come back happy than over-treat and have you regret it

As outcomes-based contracts become more common, both NICE and ICER might incorporate actual performance into their models

However, an important shift is occurring in clinical practice: we are recognizing patients with socalled lean MASLD and questioning whether our traditional therapeutic frameworks adequately address the full spectrum of disease

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Mechanism of ferroptosis and its role in type 2 diabetes mellitus