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Nevertheless, the increase of PyroGlu and decrease of Glu seems more reflecting the low ATP cellular content leading to a locking of the gamma-glutamyl cycle from the first step requiring ATP after PyroGlu synthesis

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Skeletal muscle contraction also elicits both shear stress to the surrounding arteries due to increased local blood flow and increased muscle fiber intracellular calcium concentrations via excitationcontraction coupling (Stamler and Meissner, 2001)

L.D., B.P., J.R.B., and R.M