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doi: 10.1002/alz.12558 72 RodriguesT

Sestrin2 is a leucine sensor for the mTORC1 pathway

A commenter stated that the efficiency adjustment is different from the GPCI and MP updates, in contrast to those updates, which have occurred every 3 years for decades with finite and consistent impact on affected services, the efficiency adjustment has the potential to be substantially disruptive to the fee schedule every year it is implemented

Phenylbutyrate-induced glutamine depletion in humans: Effect on leucine metabolism