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c-MYC was elevated suggesting that RRM2 -OE-TPC-1 cells may achieve the synergistic activation of multiple proliferative signaling pathways with the help of this transcription factor, accelerating tumor progression ( CDK2 , which forms a complex with Cyclin E and Cyclin A and is a key kinase regulating the G1/S transition and S-phase progression, further corroborates the phenomenon of cell cycle deregulation
Revista espaola de enfermedades digestivas : organo oficial de la Sociedad Espaola de Patologa Digestiva , 78 5, 324-5 Mock D.M
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It also activates the FAK-paxillin pathway, which gets fibroblasts and endothelial cells physically moving toward the wound [4]
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