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Clinicians treating PWS patients with GLP-1 medications typically require specialized knowledge of PWS pathophysiology and careful monitoring, as dosing and response patterns may differ from standard weight-loss populations

In the intestinal L-cells, proglucagon is cleaved by the enzyme prohormone convertase 1/3 to produce GLP-1, along with other peptides including GLP-2 and glicentin

Doing so can expose the pharmacy to FDA enforcement action

Antiemetics, vomiting Vomiting The forcible expulsion of the contents of the stomach through the mouth

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Based on this feedback, clarifications were made to the PIS regarding TMAO producer status and eligibility for Phase II of the study