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In the CONQUER and EQUIP trials, which were the major studies leading to FDA approval: Patients on the highest dose lost an average of 10.9% to 12.4% of body weight over 56 weeks

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This approach leads to improved glycemic control and substantial weight loss, with clinical trials demonstrating HbA1c reductions of 1.9% to 2.4% and mean weight loss of approximately 15-21% in the SURMOUNT-1 trial, with up to 22.5% weight loss observed in some patients at the highest doses