these processes are mediated by PC1 and PC3.2830 OXM inhibits gastrointestinal secretion and motility (so probably promoting satiety) and stimulates pancreatic enzyme secretion and intestinal glucose uptake.31 Among others (cardiovascular and central effects), GLP-1 exerts a number of gastrointestinal actions: stimulation of glucose-induced insulin secretion by upregulating insulin gene expression and potentiating all steps of insulin biosynthesis
In parallel, future research should also address the integration of GLP-1 RAs into multimodal treatment frameworks, combining pharmacological, psychotherapeutic, and lifestyle-based interventions
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Glucagon-like peptide-1 (GLP-1) plays a pivotal role in glucose homeostasis by enhancing insulin secretion, suppressing glucagon release, delaying gastric emptying, and acting on the central nervous system to regulate satiation and satiety
Every patient receives education on expected side effects, hydration protocols, and clear guidance on when to escalate concerns to medical professionals
In humans, a landmark 2023 observational study of over 80,000 patients with obesity found that those on semaglutide had a 50-56% lower incidence of alcohol use disorder compared to patients on other anti-obesity medications
