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Within this hierarchy, the gut microbiota act as an integrated modulatory layer rather than a independent predictor

2 (download XLSX Source data for Extended Data Fig

Originating as a treatment for type 2 diabetes, Semaglutide was approved by the FDA for chronic weight management in 2021, following rigorous trials that demonstrated its safety and efficacy

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While GLP-1 medications dont directly change female sex hormones, rapid weight loss and improved insulin sensitivity can indirectly trigger hormonal shift, leading to menstrual changes, mood or energy fluctuations, and considerations for bone, muscle, and mental health