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Thrombolysis remains a major strategy for the treatment of ischemic stroke

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Corticosteroids further deplete vitamin D and calcium

An 8-week trial of supervised weight reduction with low-energy diet showed a mean weight loss of 14.2 kg, and significant improvement was observed in individuals in the intervention group in forced expiratory volume at one second (FEV1), forced vital capacity (FVC), dyspnea, use of rescue medication, and number of exacerbations, compared with controls [42]

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What we do not have is a dedicated primary prevention trial showing that treating healthy adults to apoB below, for example 0.6 g/L produces better health outcomes than current practice