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The transforming growth factor- (TGF-)TGF- receptor 2 (TGFR2) signaling pathway regulates differentiation, maturation, proliferation, migration, and attachment of both ECs and pericytes [78, 79]

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The pathophysiology of severe asthma with persistent airflow limitation shares similar features with that of chronic obstructive pulmonary disease (COPD), including airway remodeling and emphysema-like changes, which complicate diagnosis and treatment [42]