Earlier this month, researchers at Harvard University published the results of their recent study, which observed an increased risk of nonarteritic anterior ischemic optic neuropathy (NAION) in patients taking semaglutide for type 2 diabetes or weight loss
It is noteworthy that in the phentermine 15 mg/topiramate 92 mg arm of CONQUER, 192 of 995 participants in the total population discontinued due to adverse events (it was unclear how many of the 664 participants with T2DM in this arm discontinued), which was notably higher than the placebo and phentermine 7.5 mg/topiramate 46 mg treatment arms (89 of 994 and 58 of 498 discontinuations due to adverse events, respectively)
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It is not clear whether GLP-1 users lost weight and, if so, how much or achieved diabetes control
Histological characterization of orphan transporter MCT14 (SLC16A14) shows abundant expression in mouse CNS and kidney
Quick Math According to recent clinical data, up to 40% of weight lost on GLP-1s is lean mass, not fat