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(iv) although cancer cells exhibit very little standard pyruvate dehydrogenase complex activity 166 , they engage in reductive carboxylation of glutamine that yields citrate destined for fatty acid synthesis, which would normally inhibit phosphofructokinase-1 (Fig

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Mechanistic Novelty Dihexa and Cerebrolysin are not direct competitors they occupy entirely different tiers of the evidence hierarchy, and comparing them reveals more about the drug development process than about relative efficacy

it profoundly affects the autonomic nervous system (ANS) and cardiovascular function

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