doi: 10.1210/jc.2018-01713 51 ZongYDengKChongWP
The Vegetarian Resource Group suggests that vegans need to have reliable sources of vitamin B12 in their diets.1 The Vegetarian Nutrition Dietetic Practice Group (VNDPG) of the Academy of Nutrition and Dietetics (the Academy) says that all vegetarians (including vegans) should include a reliable B12 source in their diets, such as fortified foods or supplements.2 And The Vegan Society goes so far as to state, What every vegan should know about B12: the only reliable sources of B12 are foods fortified with B12 and supplements.3 Its extremely important for health care professionalsas well as clientsto understand the significance and intricacies of sufficient vitamin B12 intake for vegan diets, because deficiency of this essential micronutrient is serious business
Cysteine availability is the limiting factor of GSH synthesis due to the fact that GCLc Km for cysteine, around 270 M, is roughly equal to its intracellular concentration
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