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Pleiotropic effects of the carnitine pool Carnitine can be combined with fatty acid chains of different lengths to derive a variety of acylcarnitines, which are amphiphilic because they contain hydrophilic quaternary ammonium groups and hydrophobic carbon chains [5], and acylcarnitines of different chain lengths have diverse chemical structure and metabolic pathways, making them widely involved in pathophysiology
Only one RCT aimed to evaluate the effects of PEA (600 mg b.i.d.) in combination with acetyl-carnitine in FM patients already receiving duloxetine and pregabalin
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