10.1212/WNL.0000000000001329 111
102 A range of health-promoting actions have more recently been attributed to berberine, including decreasing oxidative stress, modulating immune function, reducing inflammation, regulating carbohydrate and fat metabolism, improving mitochondrial function, and affecting epigenetic and microbiome factors
Poor sleep (thank you, night sweats and insomnia) can interfere with the tissue repair process and also make you more sensitive to pain, making joint discomfort feel more intense
Some anecdotal KLOW protocols extend to about 16 weeks
The verdict on the outcome that matters most was flat: no benefit on all-cause death, a risk ratio of 0.96 with a confidence interval from 0.65 to 1.41, at moderate certainty (Ziganshina et al., Cochrane 2023)
According to the American Academy of Ophthalmology, NAION typically develops without warning and most often affects one eye