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65 These factors occur across the lifespan and are: lower education, vision loss, high cholesterol, head injury, physical inactivity, smoking, excessive alcohol consumption, hypertension, obesity, diabetes, hearing loss, depression, infrequent social contact and air pollution

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Furthermore, a recent study of genetic variants associated with lithium responsiveness in bipolar disorder patients found a significant enrichment of genes involved in glutamatergic synapse neurotransmission, which included GSK3 and CAMK4 [175]