An in vitro study showed that vanillin inhibits the phosphorylation of MAPKs and NF-B in LPS-treated microglia, and also reduces the protein levels of COX-2 and iNOS, as well as the mRNA levels of IL-1, TNF- and IL-6 ( Vanillic acid Vanillic acid (4-hydroxy-3-methoxybenzoic acid) is an oxidized form of vanillin and can be isolated from Tianma
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57 When combined with the non-steroidal anti-inflammatory drug (NSAID) meloxicam (Vivlodex), a micronized curcumin/palmitoyl-glucosamine complex that provided 266798 mg palmitoyl-glucosamine plus 133399 mg curcumin per day, depending on body weight, allowed for the reduction of meloxicam dose (by up to 25%) while maintaining the same degree of pain mitigation based on veterinarian evaluations
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