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Mitochondria, as the primary source of ROS in mammalian cells, are particularly vulnerable, with oxidative stress contributing to mitochondrial dysfunction, energy depletion, and cell death (Cui et al., 2012)

Likewise, in male silk moth ( Bombyx mori ), the antennae specific BmGSTD4 had high GSH-conjugating activity towards 1-chloro-2, 4-dinitrobenzene (CDNB), indicating its potential role in the metabolism of xenobiotics [108]

Cellular uptake studies revealed a 5.3-fold increase in drug internalization in Caco-2 cells when encapsulated in nanoparticles

Because of its properties as an antioxidant, and its high intracellular concentration and wide distribution, its role as a potent defense mechanism against oxidative and electrophilic stress is well established

doi: 10.1016/j.jff.2024.106433

Plant Sci 42(1):3540