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At maximum doses, retatrutide has higher rates of nausea (43% vs 31%), vomiting (21% vs 12%), diarrhea (33% vs 23%), and constipation (25% vs 11%) compared to tirzepatide

For some people with end-stage kidney disease, a kidney transplant may be the best treatment option

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This study innovatively focuses on the mechanism by which FOXO4-DRI induces apoptosis in senescent endothelial cells, demonstrating that it functions by activating the p53/BCL-2/Caspase-3 signaling pathway to promote selective apoptosis of these cells

Dig Dis Sci 1979

Ulusoy, K., Doan-salamtimur, N., iner, F., Sternik, A