Although the specific mechanism is not completely clear at present, from the perspective of its important regulatory role on GABAergic neurons, the abnormality of ARX may affect the normal development and function of GABAergic neurons, leading to the imbalance of brain neural circuits, thus causing ASD related symptoms ( Dysfunction of GABAergic interneurons has been observed in animal models of ASD
Helbock HJ, Beckman KB, Shigenaga MK, Walter PB, Woodall AA, Yeo HC et al
Haub School of Business, Saint Josephs University, Philadelphia
L.JaffeE
have investigated the apparent selectivity of FOXO4-DRI peptide in regard to specifically targeting aged cells for apoptosis
What does NAD+ actually do and why does it decline with age