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*Correspondence: Liangliang Ouyang, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

As a highly specific ferroptosis inhibitor, Fer-1 surpasses phenolic antioxidants in its ability to suppress ferroptosis, particularly by inhibiting lipid ROS accumulation induced by erastin or RSL3 in HT-1080 human fibrosarcoma cells) (27)

Cell 156, 8496

However, the consistency of the step-up pattern across sequential generations of compounds (single dual triple agonist) has generated significant research interest in the triple-agonist mechanism

This algorithm is composed of a perturbation and a relaxation stage, and uses a mixture of random moves with protein structure prediction algorithms

The homogenates were prepared in MiRO5Cr using a Dounce homogenizer (1 ml, Wheaton Science) at 4050 strokes