The sprout extract of Tuscan black cabbage, a type of kale, was found to be protective against a high-fat diet in rats, restoring antioxidant and phase II enzyme levels and lowering serum lipids (total cholesterol, triacylglycerides, non-esterified fatty acids) (Melega et al., 2013)
Approximately 1,500 patients with T2D and Early Treatment Diabetic Retinopathy Study (ETDRS) level of 1075 in both eyes and no ocular or intraocular treatment for diabetic retinopathy or diabetic macular edema in the 6 months prior to screening will receive once-weekly subcutaneous semaglutide 1.0 mg or placebo for up to 5 years, with the primary endpoint of progression of 3 steps or more in ETDRS level
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However, this animal data cannot be directly extrapolated to human pregnancy, which is why most clinicians recommend discontinuing semaglutide before attempting conception to eliminate any theoretical risk
This is the sweet spot where side effects have largely resolved but therapeutic benefits are still building
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